Big Pharma Frightened After New Study Shows Cannabis is a Highly Effective Antidepressant

cannabis-anti-deprresantsBy Justin Gardner

A new study in the journal Neuropharmacology is showing yet again the incredibly diverse ways that medical cannabis can heal the body. We already know of several physical conditions it can treat—such as epileptic seizures, Crohn’s disease and neuropathic pain—but medical cannabis is also showing promise for the treatment of depression.

Researchers at the Universidad de Cantabria focused on cannabidiol (CBD), a non-psychoactive component of cannabis, finding that that CBD has fast-acting antidepressant effects that can be sustained with continued doses.

Our results demonstrate that CBD exerts fast and maintained antidepressant-like effects as evidenced by the reversal of the OBX-induced hyperactivity and anhedonia…

In conclusion, our findings indicate that CBD could represent a novel fast antidepressant drug, via enhancing both serotonergic and glutamate cortical signaling through a 5-HT1A receptor-dependent mechanism.

The scientists used an established method of research on mice that has proven to be an accurate model for human depression, allowing study of the biological causes and potential treatments. They discovered that CBD acted to reverse depression symptoms by causing an increased release of serotonin and glutamate.

Mice with the OBX surgery showed significantly reduced symptoms of hyperactivity 30 minutes after CBD was administered, in comparison to mice that were given a placebo. Continued daily administration of CBD was found to completely reverse the effects of OBX surgery on the mice’s loss of interest in sugar after one week. Examination of chemical activity within the mice’s brains indicated that CBD caused increased release of serotonin and glutamate.

Glutamate release was affected dramatically in all mice who received CBD, both immediately after the first dose and after weeks of repeated administration. The impact on serotonin was more subtle after the first dose, and it persisted over time only in mice who had OBX surgery, suggesting that this change may have occurred only in response to the depression-like conditions in the mice’s brains. —

In January we reported that people who have discovered the therapeutic uses of cannabis are giving up prescription drugs. Big Pharma is very concerned that their manufactured products could be replaced by a miraculous plant.

As we reported last month, chemical antidepressants may be causing an increase in suicides, and government-backed pill pushers are trying to hide these destructive effects. This new study brings more bad news for Big Pharma, as CBD could prove to be more effective than their notorious products.

Justin Gardner writes for, where this article first appeared.

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25 Comments on "Big Pharma Frightened After New Study Shows Cannabis is a Highly Effective Antidepressant"

  1. GrandmaAmerica | March 14, 2016 at 10:24 am | Reply

    Try God as an anti-depressant, It worked for me…….

    • rhondareichel | March 14, 2016 at 10:30 am | Reply

      God made marijuana.

      • GrandmaAmerica | March 14, 2016 at 3:17 pm | Reply

        Okay, Rhonda, what ever you need to tell your self to justify ingesting a noxious weed. More power to you. Just do not try to justifying it using God in your reasoning. Pathetic.

        • You are the pathetic one ‘GrandmaAmerica’ – where does it say that hemp is evil in your bible? What evidence do you have that hemp is a ‘noxious’ weed? Have you ever examined the source of your prejudice? Why do you support big-pharma which is surely NOT inspired by goodness but clearly has an evil agenda?

        • Man made alcohol
          God made pot
          Alcohol kills
          Pot does not
          Man made pills
          God made pot
          Pills do kill
          Pot does not
          God is everything, including him in your reasoning may just save your soul.

      • In everything that you touch, see, and sense, I AM. That I AM……. No it’s not a quote from Popeye. You are aware,,, 😉

    • Glad to hear something spiritual has helped you. May I ask which God you’re talking about though? So many gods out there, which one should I put my faith in?

      • There’s only ONE. The First Americans called him the “Great Creator”. If you have no faith in Him, you’ll have no faith in yourself.

    • EmmettGrogan | March 14, 2016 at 5:11 pm | Reply

      It’s his followers which make me depressed.

  2. They should be scared. Remember, these are people who have no problems with killing for profit.

    • Only, in places where it is illegal. Prohibition doesn’t work. Even George Washington, and Thomas Jefferson, grew cannabis.

      Note: No one kills more “for profit” then the (legal) pharmaceutical manufacturers.

      • Well,.. yes,..but they grep Hemp. I doubt Geogre Washington and Thomas Jefferson sat around huffing on a bong full of seriously sticky nugs!

        • EmmettGrogan | March 14, 2016 at 5:10 pm | Reply

          They did grow pot. Years ago, a scholar from Cambridge did research and found evidence of it, wrote an article and it was published in a magazine called Green Egg. You might be able to find it online. They also grew opium poppies and made opium. Pot and opium were used for pain before painkillers were invented. Look it up.

        • George Washington had mentioned in his letters to John Adams of his hemp crops. He referenced both his textile crop and his “bud” crop. He was growing for the high/medicine also. As Abe L. also enjoyed a bowl of the “weed” in the evenings on his veranda.

  3. I was on big pharma anti-depressents for 22 years. Finally with a cold turkey plan and smoking some pot only at night I was able to get off of them and it has been 6 years and I am doing fabulous. The first 6 months were tough. Anti-depressents don’t let you feel they keep you from going very deep with your feelings. I felt alot of things I had surpressed for 22 years. Once I got past that I have been doing excellent and I really don’t need to smoke weed anymore either.

  4. James Peters | March 14, 2016 at 5:25 pm | Reply

    Clinical trials are ongoing. When something is proven to work then it will be approved

    • Lol – you’ve GOT to be joking. Hemp is still classified as a schedule one drug that supposedly has NO medical use despite being a miracle medicine for so many things that it’s almost literally unbelievable.

      • James Peters | March 14, 2016 at 7:18 pm | Reply

        There are no valid reasons to maintain cannabis as a schedule 1 drug. It’s probably a relic of a different era when marijuana was considered a gateway drug to much harder substances or based on claims it corrupted people. However that’s completely political. GW Pharma’s Epidiolex has positive data from a global Phase III trial as a treatment of Dravet syndrome. It achieved the primary endpoint and that was the key. I know GW will arrange a meeting with the FDA to ask for this to be approved and it should be as the FDA gave it both fast track and orphan drug designation statuses. They will also ask for Sativex to be approved for the treatment of spasticity due to multiple sclerosis. I know both these drugs are in other Phase III trials as well and if they are positive then the drugs should also be approved for a range of other illnesses

        • I wish I was as optimistic as you. As far as I can see the facts do not trump the lies – especially in the case of hemp. But maybe you are right, in the case of hemp there are SO many people who would be helped by its legalization and So many people who are beginning to realize this that they may have to give way. I very much hope so.

    • Something shouldn’t have to be “approved” by someone else before people can eat drink otherwise consume something, (least of all “approved” by a demonstrably corrupt agency such as the FDA) Only slaves prisoners and children have someone else decide for them what they consume

    • It’s been approved and proven by humanity for over five thousand years. Now we have a select group of paid shills that have the audacity to tell us they will approve it……………. FUNNIEEE!!! That’s as funny as the USDA telling us they are going to study and regulate cow manure’s use as a fertilizer.

  5. THC and CBD are in love with our DNA.
    Move to Colorado and imbibe for the the health of it.

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  6. Never underestimate the evil terrorist empire(illuminati). They are masters of human psychology and planning. Legalizing pot is no luck on our part.

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